Dynamic evolution of ponatinib‐resistant mutations in BCR–ABL1 ‐positive leukaemias revealed by next‐generation sequencing
Author:
Affiliation:
1. Division of Pathology & Laboratory Medicine Hebei Yanda Lu Daopei Hospital Langfang China
2. Beijing Lu Daopei Institute of Hematology Beijing China
3. Division of Pathology & Laboratory Medicine Beijing Lu Daopei Hospital Beijing China
Publisher
Wiley
Subject
Hematology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.17068
Reference12 articles.
1. Prospective assessment of NGS-detectable mutations in CML patients with nonoptimal response: the NEXT-in-CML study
2. BCR-ABL1 compound mutants display differential and dose-dependent responses to ponatinib
3. Novel TKI-resistant BCR-ABL1 gatekeeper residue mutations retain in vitro sensitivity to axitinib
4. BCR-ABL1 Compound Mutations Combining Key Kinase Domain Positions Confer Clinical Resistance to Ponatinib in Ph Chromosome-Positive Leukemia
5. Compound mutations in BCR-ABL1 are not major drivers of primary or secondary resistance to ponatinib in CP-CML patients
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