A phase 1 clinical trial evaluating marizomib, pomalidomide and low-dose dexamethasone in relapsed and refractory multiple myeloma (NPI-0052-107): final study results

Author:

Spencer Andrew1,Harrison Simon23,Zonder Jeffrey4,Badros Ashraf5,Laubach Jacob6ORCID,Bergin Krystal1,Khot Amit2,Zimmerman Todd7,Chauhan Dharminder6,Levin Nancy8,MacLaren Ann8ORCID,Reich Steven D.8,Trikha Mohit8,Richardson Paul6ORCID

Affiliation:

1. Alfred Health-Monash University; Melbourne Australia

2. Peter MacCallum Cancer Centre; East Melbourne Australia

3. Melbourne University; Melbourne Australia

4. Karmanos Cancer Center; Detroit MI

5. University of Maryland Medical Center; Baltimore MD USA

6. Dana Farber Cancer Institute; Boston MA USA

7. Comprehensive Cancer Center; The University of Chicago Medicine; Chicago IL USA

8. Triphase Accelerator; San Diego CA USA

Publisher

Wiley

Subject

Hematology

Reference41 articles.

1. Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells;Altun;Cancer Research,2005

2. Cardiac complications in relapsed and refractory multiple myeloma receiving single agent carfilzomib;Atrash;Blood Cancer Journal,2015

3. Marizomib for CNS-multiple myeloma;Badros;British Journal of Haematology,2017

4. Investigation of pharmacodynamics and predictive biomarkers to define response to proteasome inhibitor marizomib in glioma. In Proceedings of the 107th Annual Meeting of the American Association of Cancer Research, 2016 Apr16-20, New Orleans, LA;Bota;Cancer Research,2016

5. A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from bortezomib;Chauhan;Cancer Cell,2005

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