Lrp1/LDL Receptor Play Critical Roles in Mannose 6-Phosphate-Independent Lysosomal Enzyme Targeting

Author:

Markmann Sandra1,Thelen Melanie2,Cornils Kerstin3,Schweizer Michaela4,Brocke-Ahmadinejad Nahal2,Willnow Thomas5,Heeren Joerg6,Gieselmann Volkmar2,Braulke Thomas1,Kollmann Katrin1

Affiliation:

1. Department for Biochemistry, Children's Hospital; University Medical Center Hamburg-Eppendorf; D-20246 Hamburg Germany

2. Institute of Biochemistry and Molecular Biology; University of Bonn; Nussallee 11 D-53115 Bonn Germany

3. Research Department Cell and Gene Therapy, Clinic for Stem Cell Transplantation; University Medical Center Hamburg-Eppendorf; D-20246 Hamburg Germany

4. Center for Molecular Neurobiology Hamburg, ZMNH; University Medical Center Hamburg-Eppendorf; 20246 Hamburg Germany

5. Max Delbrück Center for Molecular Medicine; 13125 Berlin-Buch Germany

6. Department of Biochemistry and Molecular Cell Biology; University Medical Center Hamburg-Eppendorf; D-20246 Hamburg Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Cell Biology,Genetics,Molecular Biology,Biochemistry,Structural Biology

Reference69 articles.

1. UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase. Proposed enzyme for the phosphorylation of the high mannose oligosaccharide units of lysosomal enzymes;Reitman;J Biol Chem,1981

2. UDP-N-acetylglucosamine:lysosomal enzyme precursor N-acetylglucosamine-1-phosphotransferase. Partial purification and characterization of the rat liver Golgi enzyme;Waheed;J Biol Chem,1982

3. Identification of a rat liver alpha-N-acetylglucosaminyl phosphodiesterase capable of removing “blocking” alpha-N-acetylglucosamine residues from phosphorylated high mannose oligosaccharides of lysosomal enzymes;Varki;J Biol Chem,1980

4. Processing of the phosphorylated recognition marker in lysosomal enzymes. Characterization and partial purification of a microsomal alpha-N-acetylglucosaminyl phosphodiesterase;Waheed;J Biol Chem,1981

5. Mannose 6-phosphate receptors: new twists in the tale;Ghosh;Nat Rev Mol Cell Biol,2003

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