Synthesis of a glycodendrimer incorporating multiple mannosides on a glucoside core

Abstract

The synthesis of a glycodendrimer by incorporating repetitive mannoside units onto a glucoside core was carried out to multivalently probe fundamental carbohydrate–protein interactions. The dendritic structure was constructed by a modified procedure that utilized multiple glycosylations between a thioether glycosyl donor and five elongated spacer arms of a glycosyl acceptor. The completed dendrimer bears a full carbohydrate structure, and thus should find its potential application in the study of mannose–lectin interactions.