Author:
Bobb Dolores,Downs Cora M.
Abstract
The phenomenon of Coxiella burnetii phase variation has been further studied. The phase 2 Nine Mile strain employed would not stimulate late-appearing, phase 1 reacting complement-fixing antibody in guinea pigs when employed either as a killed or an infecting suspension. However, this failure was not the result of a loss of component I since the antibody could be readily induced if adjuvants were employed or booster shots were given. Yolk sacs of chick embryos infected with the phase 1 strain yielded about 4 or 5 times as much rickettsial complement-fixing material as eggs infected with the phase 2 strain. The phase 1 rickettsiae appeared more hydrophilic and were more efficiently extracted from the yolk material. Immunized guinea pigs did not give a positive skin test until the time of appearance of phase 1 reacting antibody in the serum. The nomenclature of phase antigens, antibodies, and rickettsial strains is discussed briefly.
Publisher
Canadian Science Publishing
Subject
Genetics,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Immunology,Microbiology
Cited by
10 articles.
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