Bio-Fe3O4-MNPs catalyzed green synthesis of pyrrolo[2,1-a]isoquinoline derivatives using isoquinolium bromide salts: study of antioxidant activity

Abstract

In this research, a novel, one-pot, efficient procedure with high yield for the synthesis of pyrrolo[2,1-a]isoquinoline derivatives using multi-component reaction of isoquinoline, alkyl bromides, and triphenylphosphine in the presence of Fe3O4-MNPs as catalyst under solvent-free conditions at room temperature is investigated. This study highlights an easy, simple, rapid, and clean method for the preparation of pyrrolo[2,1-a]isoquinoline derivatives. The Fe3O4-MNPs in these reactions were produced employing a green procedure by reduction of ferric chloride solution with pomegranate peel water extract. Additionally, antioxidant activity was studied for the some newly synthesized compounds such as 5a–5d using the DPPH radical trapping and reducing potential of ferric ion experiments and comparing the results with the results of synthetic antioxidants (2-tert-butylhydroquinone, TBHQ; butylated hydroxytoluene, BHT). As a result, compounds 5a–5d show trace DPPH radical trapping and excellent reducing power of ferric ion.