Synthesis and characterization of methyl substituted 3-hydroxypyridin-4-ones and their complexes with iron(III)-Reference-Cited by-同舟云学术

Synthesis and characterization of methyl substituted 3-hydroxypyridin-4-ones and their complexes with iron(III)

Published:2018-03 Issue:3 Volume:96 Page:293-298
ISSN:0008-4042
Container-title:Canadian Journal of Chemistry
language:en
Short-container-title:Can. J. Chem.

Author:

Cheng Chen¹,Chen Yulin¹,Cao Yue¹,Ma Yongmin¹,Hider Robert C.²

Affiliation:

1. College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, P. R. China, 311402.

2. Institute of Pharmaceutical Science, King’s College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.

Abstract

Methyl substituted 3-hydroxypyridin-4(1H)-ones have been synthesized. The pKa values and Fe3+ affinity constants of these ligands were studied. The introduction of an electron-donating methyl group at a different position of pyridinone ring markedly influences the pKa values of 3-hydroxy and 4-oxo groups. The pFe3+ values were also affected and are in the range of 17.6–20.7. The findings can be used to guide a design of 3-hydroxypyridin-4-ones with desirable pKa and pFe3+ values.

Publisher

Canadian Science Publishing

Subject

Organic Chemistry,General Chemistry,Catalysis

Link

http://www.nrcresearchpress.com/doi/pdf/10.1139/cjc-2017-0545

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