β-1 adrenoceptors and AT1 receptors may not be involved in catecholamine-induced lethal arrhythmias

Author:

Adameova Adriana1,Elimban Vijayan2,Ganguly Paul K.2,Dhalla Naranjan S.2

Affiliation:

1. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University 832 32 Bratislava, Odbojarov 10, Slovakia.

2. Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre and Department of Physiology & Pathophysiology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R2H 2A6, Canada.

Abstract

An excessive amount of catecholamines produce arrhythmias, but the exact mechanisms of this action are not fully understood. For this purpose, Sprague–Dawley rats were treated with or without atenolol, a β1-adrenoceptor blocker (20 mg/kg per day), for 15 days followed by injections of epinephrine for cumulative doses of 4 to 128 μg/kg. Another group of animals were pretreated with losartan, an angiotensin receptor (AT1) blocker (20 mg/kg per day), for comparison. Control animals received saline. Varying degrees of ventricular arrhythmias were seen upon increasing the dose of epinephrine, but the incidence and duration of the rhythm abnormalities as well as the number of episodes and severity of arrhythmias were not affected by treating the animals with atenolol or losartan. The levels of both epinephrine and norepinephrine were increased in the atenolol-treated rats but were unchanged in the losartan-treated animals after the last injection of epinephrine; the severity of arrhythmias did not correlate with the circulating catecholamine levels. These results indicate that both β1-adrenoceptors and AT1 receptors may not be involved in the pathogenesis of catecholamine-induced arrhythmias and support the view that other mechanisms, such as the oxidation products of catecholamines, may play a crucial role in the occurrence of lethal arrhythmias.

Publisher

Canadian Science Publishing

Subject

Physiology (medical),Pharmacology,General Medicine,Physiology

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Future scope and challenges for congestive heart failure: moving toward development of pharmacotherapy;Canadian Journal of Physiology and Pharmacology;2022-09-01

2. Effects of atenolol injected into the nucleus accumbens septi in rats in the elevated plus-maze test;Journal of Basic and Clinical Physiology and Pharmacology;2020-06-29

3. Role of Oxidative Stress in the Genesis of Ventricular Arrhythmias;International Journal of Molecular Sciences;2020-06-12

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