Effects of atenolol injected into the nucleus accumbens septi in rats in the elevated plus-maze test-Reference-Cited by-同舟云学术

Effects of atenolol injected into the nucleus accumbens septi in rats in the elevated plus-maze test

Published:2020-06-29 Issue:6 Volume:31 Page:
ISSN:2191-0286
Container-title:Journal of Basic and Clinical Physiology and Pharmacology
language:en
Short-container-title:

Author:

Llano López Luis H.¹²³^ORCID,Melonari Pablo²,Olguin Marisa¹,Fraile Miriam Débora¹,Landa Adriana I.¹²,Gargiulo Pascual A.¹²

Affiliation:

1. National Council of Scientific and Technological Research (CONICET), Laboratory of Neurosciences and Experimental Psychology , Ciudad Universitaria, Parque General San Martin , Mendoza , Argentina

2. National University of Cuyo, Faculty of Medical Sciences, Area of Pharmacology, Department of Pathology , Ciudad Universitaria, Parque General San Martin , Mendoza , Argentina

3. Servicio de Terapia Intensiva Infantil , Hospital Pediátrico Dr. Humberto Notti, Mendoza , Argentina

Abstract

Abstract Background In previous studies, we have observed that glutamate antagonists injected within the nucleus accumbens septi (NAS) induced an anxiolytic-like effect in the elevated plus maze (EPM) test in rats. In the present study, the effect of Atenolol, a specific Beta Adreno-receptor antagonist in the EPM was studied in male rats bilaterally cannulated NAS. Methods Rats were divided into five groups that received either 1 μL injections of saline or atenolol in different doses (0.75, 1 or 2 μg/1 μL, n=15–16) 15 min before testing. Results Time Spent in the Open Arm was modified by treatment (F=4.563, p=0.006, df 3). This was increased by the lowest dose of atenolol (p<0.05), by the medium doses (p<0.001) and also by the highest dose (p<0.01). Time per Entry was modified by treatment (F=4.54, p=0.06, df 3). This parameter was increased by the lowest dose of atenolol (p<0.01), but not for the medium and higher doses. Conclusions We conclude that Atenolol beta receptor blockade in the accumbens lead to an anxiolytic-like effect related to an increase in the time spent in the open arm and in the time per entry, showing specific behavioral patterns.

Funder

Fundación Corporación Tecnológica Latinoamericana (FUCOTEL).

Volkswagen Foundation

Universidad Nacional de Cuyo

Publisher

Walter de Gruyter GmbH

Subject

Drug Discovery,Pharmacology,General Medicine,Physiology

Reference47 articles.

1. Chronister, RB, DeFrance, JF. Nucleus Accumbens in historical perspective. In: Chronister, RB, DeFrance, JF, editors. The Neurobiology of Nucleus Accumbens, Haer Institute for Electrophysiological Research; 1981:1–6 p.

2. Chuhma, N, Mingote, S, Kalmbach, A, Yetnikoff, L, Rayport, S. Heterogeneity in dopamine neuron synaptic actions across the striatum and its relevance for schizophrenia. Biol Psychiatry 2017;81:43–51. https://doi.org/10.1016/j.biopsych.2016.07.002.

3. Groenewegen, HJ, Vermeulen-van Der See, E, Te Kortschot, A, Witter, MP. Organization of the projections from the subiculum to the ventral stratum in the rat: A study using anterograde transport of Phasealus vulgaris leucoaglutinin. Neurosci 1987;23:103–20. https://doi.org/10.1016/0306-4522(87)90275-2.

4. Mogenson, GJ, Jones, DL, Yim, CY. From motivation to action: Functional interface between the limbic system and the motor system. Prog Neurobiol 1980;14:69–97. https://doi.org/10.1016/0301-0082(80)90018-0.

5. Pennartz, CMA, Groenewegen, HJ, Lopes da Silva, F. The nucleus accumbens as a complex of functionally distinct neuronal ensembles: An integration of behavioural, electrophysiological and anatomical data. Prog Neurobiol 1994;42:719–61. https://doi.org/10.1016/0301-0082(94)90025-6.