Influence of treatment with quercetin on lipid parameters and oxidative stress of pregnant diabetic rats-Reference-Cited by-同舟云学术

Influence of treatment with quercetin on lipid parameters and oxidative stress of pregnant diabetic rats

Published:2013-02 Issue:2 Volume:91 Page:171-177
ISSN:0008-4212
Container-title:Canadian Journal of Physiology and Pharmacology
language:en
Short-container-title:Can. J. Physiol. Pharmacol.

Author:

Pereira Braga Camila¹,Momentti Ana Carolina¹,Barbosa Peixoto Fernando¹,de Fátima Ferreira Baptista Rafaela²,dos Santos Felipe André¹,Fava Fábio Henrique¹,Fernandes Ana Angélica Henrique¹

Affiliation:

1. Departamento de Química e Bioquímica, Instituto de Biociências, Campus de Botucatu, Universidade Estadual Paulista “Júlio de Mesquita Filho”, UNESP, 18618-970, Botucatu, São Paulo, Brazil.

2. Departamento de Farmacologia, Instituto de Biociências, Campus de Botucatu, Universidade Estadual Paulista “Júlio de Mesquita Filho”, UNESP, 18618-970, Botucatu, São Paulo, Brazil.

Abstract

Among the numerous coadjuvant therapies that could influence the incidence and progression of diabetic complications, antioxidants and flavonoids are currently being tested in clinical trials. We investigated the effect of quercetin on biochemical parameters in streptozotocin-induced (60 mg/kg body mass, by intraperitoneal injection) diabetic rats. A total of 32 female Wistar rats were distributed among 4 groups as follows: control (G1); control treated with quercetin (G2); diabetic (G3); and diabetic treated with quercetin (G4). Quercetin administered to pregnant diabetic rats controlled dyslipidemia and improved lipid profiles in diabetes mellitus, regulated oxidative stress by reducing the generation of lipid hydroperoxides, and increased the activity of the antioxidant enzyme glutathione peroxidase.

Publisher

Canadian Science Publishing

Subject

Physiology (medical),Pharmacology,General Medicine,Physiology

Link

http://www.nrcresearchpress.com/doi/pdf/10.1139/cjpp-2012-0173

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