Repetitive magnetic stimulation of the phrenic nerves for diaphragm conditioning: a normative study of feasibility and optimal settings

Author:

Adler Dan123,Gottfried Stewart B.24,Bautin Nathalie25,Mirkovic Tomislav6,Schmidt Matthieu2,Raux Mathieu27,Pavlovic Dragan28,Similowski Thomas12,Demoule Alexandre129

Affiliation:

1. Assistance Publique – Hôpitaux de Paris, Service de Pneumologie et Réanimation et Centre de Neurostimulation Respiratoire, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

2. Université Paris 6 – Pierre et Marie Curie, ER10 Paris, France.

3. Service de pneumologie, Hôpital Cantonal Universitaire de Genève, Genève, Suisse.

4. Divisions of Respiratory and Critical Care Medicine, Department of Medicine, McGill University Health Centre, Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.

5. Assistance Publique - Hôpitaux de Paris, Service Central d’Explorations Fonctionnelles Respiratoires, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

6. Clinical Departments for Anesthesiology and Surgical Intensive Care, University Medical Center, Ljubljana, Slovenia.

7. Assistance Publique – Hôpitaux de Paris, Département d’Anesthésie - Réanimation, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

8. Klinik und Poliklinik für Anästhesiologie und Intensivmedizin, Ernst-Moritz-Arndt University, Greifswald, Germany.

9. Service de Pneumologie et Réanimation, Groupe Hospitalier Pitié-Salpêtrière, 47-83 boulevard de l’Hôpital, 75651 Paris cedex 13, France.

Abstract

Electrical stimulation can enhance muscle function. We applied repetitive cervical magnetic phrenic stimulation (rCMS) to induce diaphragm contractions in 7 healthy subjects (800 ms trains; transdiaphragmatic pressure (Pdi) measurements; tolerance ratings). Each rCMS train produced a sustained diaphragm contraction. Sixty-five percent of the maximal available output at 15 Hz proved the best compromise between Pdi and discomfort with nonfatiguing contractions. rCMS appears feasible and should be investigated for diaphragm conditioning in appropriate clinical populations.

Publisher

Canadian Science Publishing

Subject

Physiology (medical),Nutrition and Dietetics,Physiology,General Medicine,Endocrinology, Diabetes and Metabolism

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