Author:
Hawkins W. W.,O'Neill A. N.
Abstract
Laminarin, a polysaccharide from brown seaweeds, has been sulphated to produce compounds which show anticoagulant activity in blood in vivo. Derivatives of sulphamic acid were more active than simple sulphate esters, although the amount of sulphate also affected the activity. When tested in rats one sulphated β-aminoethyl ether derivative was 40–50% as potent as heparin, and one ester about 30%. Tests with rats and dogs indicated no harmful effects in the doses used.
Publisher
Canadian Science Publishing
Cited by
8 articles.
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