Protective effect of essential oil of Cinnamomum verum bark on hepatic and renal toxicity induced by carbon tetrachloride in rats

Author:

Bellassoued Khaled1,Ghrab Ferdaws2,Hamed Houda1,Kallel Rim3,van Pelt Jos4,Lahyani Amina5,Ayadi Fatma Makni5,El Feki Abdelfattah1

Affiliation:

1. Department of Life Sciences, Animal Ecophysiology Laboratory, Faculty of Sciences of Sfax, University of Sfax, BP 1171, 3000 Sfax, Tunisia.

2. Coastal and Urban Environments, National Engineering School of Sfax, University of Sfax, BP 1173, 3038 Sfax, Tunisia.

3. Anatomopathology Laboratory, Habib Bourguiba University Hospital, Faculty of Medicine of Sfax, University of Sfax, 3029 Sfax, Tunisia.

4. Laboratory of Clinical Digestive Oncology, Department of Oncology, KU Leuven, 3000 Leuven, Belgium.

5. Biochemistry Laboratory, Habib Bourguiba University Hospital, 3029 Sfax, Tunisia.

Abstract

The inner bark of cinnamon (Cinnamomum verum) is widely used as a spice. Cinnamon plants are also a valuable source of essential oil used for medicinal purposes. The present study aimed to investigate the composition and in vitro antioxidant activity of essential oil of C. verum bark (CvEO) and its protective effects in vivo on CCl4-induced hepatic and renal toxicity in rats. Groups of animals were pretreated for 7 days with CvEO (70 or 100 mg/kg body weight) or received no treatment and on day 7 a single dose of CCl4 was used to induce oxidative stress. Twenty-four hours after CCl4 administration, the animals were euthanized. In the untreated group, CCl4 induced an increase in serum biochemical parameters and triggered oxidative stress in both liver and kidneys. CvEO (100 mg/kg) caused significant reductions in CCl4-elevated levels of alanine transaminase, aspartate transaminase, alkaline phosphatase, γ-glutamyl transferase, lactate dehydrogenase, total cholesterol, triglycerides, low-density lipoprotein, urea, and creatinine and increased the level of high-density lipoprotein compared with the untreated group. Moreover, pretreatment with CvEO at doses of 70 and 100 mg/kg before administration of CCl4 produced significant reductions in thiobarbituric acid reactive substances and protein carbonyl levels in liver and kidney tissues compared with the untreated group. The formation of pathological hepatic and kidney lesions induced by the administration of CCl4 was strongly prevented by CvEO at a dose of 100 mg/kg. Overall, this study suggests that administration of CvEO has high potential to quench free radicals and alleviate CCl4-induced hepatorenal toxicity in rats.

Publisher

Canadian Science Publishing

Subject

Physiology (medical),Nutrition and Dietetics,Physiology,General Medicine,Endocrinology, Diabetes and Metabolism

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