PHOSPHOLIPIDS: I. STUDIES ON THE THROMBOPLASTIC AND ANTICLOTTING ACTIVITY OF PHOSPHOLIPIDS

Abstract

Preparative thin-layer chromatography, combined with published procedures, has facilitated the isolation of chromatographically homogeneous phosphatidylserine, phosphatidylethanolamine, and lysophosphatidylethanolamine. The effect of these compounds and their mixtures on blood coagulation has been studied in the thromboplastin-generation test. Evidence is produced to demonstrate that the results of such tests for anticlotting activity are dependent on the choice of a standard clotting agent.