BLOOD PLATELET FLUCTUATION CONSECUTIVE TO TRAUMA AND SURGICAL INTERVENTION IN THE RAT, A POSSIBLE STRESS EFFECT

Author:

Latour J. G.,Renaud S.

Abstract

The typical blood platelet fluctuation repeatedly observed in man following surgical interventions and characterized by thrombocytopenia during the first 2 days and thrombocytosis after 5 to 8 days, has been reproduced in rats subjected to certain procedures, provided these were accompanied by severe tissue damage. An E. coli endotoxin injected intravenously or intraperitoneally induced a similar fluctuation and markedly potentiated the effects of the tissue damage on the blood platelets. This variation in the platelet count could be a stress effect, since it was completely reproduced by forced immobilization in the absence of any gross tissue damage. Ether anesthesia seems to reduce the magnitude of this stress-induced platelet fluctuation.

Publisher

Canadian Science Publishing

Subject

Physiology (medical),Pharmacology,General Medicine,Physiology

Reference6 articles.

Cited by 6 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. EFFECT OF FRACTURE ON RAT PLATELETS;Acta Pathologica Microbiologica Scandinavica Section A Pathology;2009-08-15

2. Influence of partial hepatectomy on the megakaryocytopoiesis of the spleen;Research in Experimental Medicine;1978-10

3. BLOOD LEVELS OF THROMBOCYTES IN BURNED PATIENTS;The Journal of Trauma: Injury, Infection, and Critical Care;1972-07

4. The recalcification plasma clotting time. A valuable general clotting test in man and rats;Canadian Journal of Physiology and Pharmacology;1969-08-01

5. Prevention by a Glucocorticoid of the Thrombotic and Hemorrhagic Tendencies Consecutive to Shock and Surgical Intervention in Rat;Thrombosis and Haemostasis;1969

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