Novel flow injection spectrophotometric determination of ranitidine in pharmaceuticals

Abstract

A novel flow injection spectrophotometric determination of ranitidine in pharmaceuticals is reported. The method is based on a compound formed in a reaction using ranitidine with and potassium permanganate in neutral media, which can be monitored at 430 nm. Under optimal conditions, an analytical curve was constructed, which was linear in the range between 5.0 × 10−5 and 1.0 × 10−3 mol L−1 with a detection limit of 1.0 × 10−5 mol L−1. In addition, the sample throughput was 60 h−1 and the obtained results for commercial formulation samples by applying the proposed method were in good agreement with labeled values and those obtained by a reference method at a 95% confidence level.