THE ANTIMICROBIAL ACTIVITIES OF CARBONYL AND THIOCARBAMOYL DISULFIDES

Abstract

Thirteen unsymmetrical disulfides of the structure —C(=X)SS—, where X is O or S, were evaluated for bactericidal and fungistatic activity under conditions simulating an industrial environment. Some carbonyl disulfides, RC(O)SSR′, were active fungistatic agents and promising bactericides. Some of the thiocarbamoyl disulfides, R2NC(S)SSR′, were found to be promising fungistatic agents and also showed significant bactericidal activity. Correlations of biological activity with chemical properties are discussed.