Viral protease inhibitors affect the production of virulence factors inCryptococcus neoformans-Reference-Cited by-同舟云学术

Viral protease inhibitors affect the production of virulence factors inCryptococcus neoformans

Published:2012-07 Issue:7 Volume:58 Page:932-936
ISSN:0008-4166
Container-title:Canadian Journal of Microbiology
language:en
Short-container-title:Can. J. Microbiol.

Author:

Sidrim J.J.C.¹,Perdigão-Neto L.V.¹²,Cordeiro R.A.¹,Brilhante R.S.N.¹,Leite J.J.G.¹,Teixeira C.E.C.¹,Monteiro A.J³,Freitas R.M.F.³,Ribeiro J.F.¹,Mesquita J.R.L.⁴,Gonçalves M.V.F.⁴,Rocha M.F.G.¹⁵

Affiliation:

1. Department of Pathology and Legal Medicine, School of Medicine, Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Federal University of Ceará, Campus do Porangabussu, Rua Cel. Nunes de Melo, 1315, Rodolfo Teófilo CEP 60430-275, Fortaleza-CE, Brazil.

2. Medical Staff, São José Hospital, Fortaleza, Ceará, Brazil.

3. Department of Statistics and Applied Mathematics, Federal University of Ceará, Fortaleza, Ceará, Brazil.

4. Microbiology Laboratory, São José Hospital, Fortaleza, Ceará, Brazil.

5. Veterinary School, Postgraduate Program in Veterinary Sciences, State University of Ceará, Fortaleza, Ceará, Brazil.

Abstract

The effects of the protease inhibitors saquinavir, darunavir, ritonavir, and indinavir on growth inhibition, protease and phospholipase activities, as well as capsule thickness of Cryptococcus neoformans were investigated. Viral protease inhibitors did not reduce fungal growth when tested in concentrations ranging from 0.001 to 1.000 mg/L. A tendency toward increasing phospholipase activity was observed with the highest tested drug concentration in a strain-specific pattern. However, these drugs reduced protease activity as well as capsule production. Our results confirm a previous finding that antiretroviral drugs affect the production of important virulence factors of C. neoformans.

Publisher

Canadian Science Publishing

Subject

Genetics,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Immunology,Microbiology

Link

http://www.nrcresearchpress.com/doi/pdf/10.1139/w2012-075

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