Author:
Belfares Lamia,Perrier Michel,Ramsay Bruce A.,Ramsay Juliana A.,Jolicoeur Mario,Chavarie Claude
Abstract
During the growth phase of Alcaligenes eutrophus, it was observed that the concentrations of glucose and ammonium ions are inhibitory at a certain level, which affects the specific growth rate. Moreover, it has been established from previous work that (an) unidentified substance(s) inhibit(s) the growth at biomass concentrations above 10 g∙L−1. A model taking into account these multiple inhibitory factors is proposed to predict the growth of A. eutrophus. The model parameters were determined by batch experiments except for the parameter associated with inhibition at high biomass concentration. This parameter was estimated by a classical optimization method. The validity of the model was tested by comparing the model predictions with experimental data obtained in batch and transient continuous fermentations and with literature data.Key words: A. eutrophus, inhibitory product, high biomass concentration.
Publisher
Canadian Science Publishing
Subject
Genetics,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Immunology,Microbiology
Cited by
19 articles.
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