Voltammetric Assessment of 8-Oxoguanine at a Nano-Structured Carbon Materials Based Modified Glassy Carbon Electrode

Abstract

In this study, we have investigated the voltammetric behavior of 8-Oxoguaine on a Multi walled carbon nanotubes / Carbon black modified glassy carbon electrode. The voltammetric oxidation of 8-Oxoguaine on modified electrode was electro-catalytic in nature. The voltammetric oxidation of the substrate was a pH dependent reversible process. Using cyclic voltammetry, a method for the determination of 8-Oxoguaine was developed. At a pH of 7.4 in phosphate buffer solution, the concentration of 8-Oxoguanine was linear from 30 to 100 μM. The detection limit and quantification limit of 8.38 μM and 27.95 μM were obtained from calibration graph, respectively. The modified electrode shows good recovery and reproducibility with relative standard deviation of 2.12%. The inter-day and intra-day assays were also studied.