This chapter summarizes some key findings of the book, discuss the challenges for, and opportunities of, the Sustainable Development Goals by identifying several conditions that might determine their successful implementation, and also suggest some possible avenues for further research. The approach of “global governance through goals”—and the Sustainable Development Goals as a prime example—is marked by a number of key characteristics, including its detachment from the international legal system, weak institutional arrangement, global inclusion and comprehensive goal-setting process, and granting much leeway to national choices and preferences. Those characteristics are reflected in the challenges for implementation, including those of developing indicators and institutional arrangements, tailoring implementation at national or stakeholder levels, and securing policy integration. Further research is needed in addressing these challenges, which requires inter- and transdisciplinary research development.