ASSOCIATIONS BETWEEN STRUCTURAL AND FUNCTIONAL STATUS OF MYOCARDIUM AND SERUM LEVELS OF NT-proBNP AND ST2 IN PATIENTS WITH COMBINED CARDIAC PATHOLOGY

Abstract

Damage to the heart under essential hypertension manifests a combination of changes in the left ventricle, left atrium, and coronary arteries resulted from a chronic elevation in blood pressure. Hypertension increases the load on the heart, causing structural and functional changes in the myocardium. Associations between clinical, laboratory and instrumental indicators and the levels of various biomarkers, which characterize the specificity and severity of systemic processes occurring in the cardiovascular system and can also be used for predicting the prognosis of diseases, are of undoubted practical interest. The aim of this study was to research the associations between the structural and functional state of the myocardium and the levels of serum NT-proBNP and ST2 in hypertensive patients with / without chronic coronary disease. Materials and methods. 118 patients with stage II hypertension with / without chronic coronary disease were included in the study. For all patients, both the main indicators of the structural and functional state of the myocardium according to echocardiography and serum levels of NT-proBNP and ST2 were additionally measured on the 2-3rd day of hospital stay when optimal therapy was being selected. Results. The obtained data indicate that a relatively low level of NT-proBNP is associated with a significant increase in the size of the right atrium and the right atrial index and the frequency of cases with concentric hypertrophy of the left ventricle compared to intermediate and relatively high levels of the neurohormone. The patients with relatively low neurohormone level demonstrate a significant increase in end-diastolic size and left atrial size compared with only intermediate levels. The results of the analysis of changes in echocardiogram indicators depending on the level of ST2 in plasma demonstrate the complete absence of any reliable changes between the selected groups.