CURRENT APPROACHES OF EUCAST COMMITTEE TO DETERMINING SUSCEPTIBILITY OF ODONTOGENIC INFECTIONS TO ANTIBIOTICS

Abstract

Introduction. Order of the Ministry of Health "On approval of guidelines “Determination of susceptibility of microorganisms to antibacterial drugs", dated 05.04.2007, № 167, was cancelled because the results included in the above document differed significantly from the American standards of sensitivity CLSI 2021, and European standards EUCAST of the same year. This created the preconditions for the revision of the regulatory framework in this area, its updating and bringing in line with international standards. The aim of this work is to identify and systematize modern approaches to determining the susceptibility of the main pathogens of odontogenic infections to antibiotics in accordance with current EUCAST quality control tables. Results. The microbiota of patients in the departments of maxillofacial surgery is usually represented by a limited list of opportunistic pathogens including Staphylococcuss spp., Enterococcus spp., Streptococcus spp., Klebsiella spp. and Candida spp. However, despite the stable quality of microbiota in odontogenic foci of infection, their sensitivity to antibacterials is subject to significant changes and requires careful review and constant monitoring. First of all, since 2019, the EUCAST Committee has changed the definition of categories of susceptibility of microorganisms to antibiotics, according to which the term "moderately sensitive" has been replaced by the term "sensitive to high exposure", and introduced the concept of screening for susceptibility testing. Conclusion. Thus, modern approaches to determining the susceptibility of major pathogens of odontogenic infections to antibiotics are based on in-depth research and careful analysis of clinical cases. Given the constant change in the spectrum of dominant pathogens and their biological properties, the standards for determining the sensitivity to antimicrobial drugs have undergone significant changes in Ukraine and around the world.