Affiliation:
1. Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Abstract
Curcumin is a chemical compound with antioxidant properties as well as strong anti-inflammatory, antiviral, analgesic, antimicrobial and antitumor effect, contained in the tuberous rhizomes of the turmeric plant (Curcuma longa). Curcumin derivatives are being intensively studied as potential drugs – antitumor drugs for the treatment of certain forms of cancer. The presence of reactive functional groups makes curcumin a convenient starting compound for the further chemical modification. The esters of curcumin and 5-phenylisoxazole-3-carboxylic acid, 5-(p-tolyl)isoxazole-3-carboxylic acid, 4,5- dichloroisothiazole-3-carboxylic acid and adduct of 5-(p-tolyl)isoxazol-3-carbaldehyde with curcumin were synthesized. Esters were obtained by acylation of curcumin with heterocycle-containing carboxylic acid chloride in diethyl ether in the presence of triethylamine. The IR and NMR spectra of the obtained compounds are described.
Publisher
Publishing House Belorusskaya Nauka
Subject
Inorganic Chemistry,Organic Chemistry,Chemistry (miscellaneous),Analytical Chemistry
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1. Chemical modification of different compounds with nitrogen-containing heterocycles;Proceedings of the National Academy of Sciences of Belarus, Chemical Series;2021-09-05