Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states

Author:

Chen Dan,Jansson Anna,Sim Daniel,Larsson Andreas,Nordlund Pär

Funder

Nanyang Technological University

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference33 articles.

1. Chromosome breakage induced by thymidylate stress in thymidylate synthase-negative mutants of mouse FM3A cells;Hori;Cancer Res,1984

2. Thymineless death and genetic events in mammalian cells;Seno;Basic Life Sci,1985

3. Standing the test of time: targeting thymidylate biosynthesis in cancer therapy;Wilson;Nat. Rev. Clin. Oncol,2014

4. Thymidylate synthase inhibitors;Ackland;Update Cancer Therap,2006

5. Molecular basis of antifolate resistance;Assaraf;Cancer Metastasis Rev,2007

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