Transcriptional Inhibition of the Mecp2 Promoter by MeCP2E1 and MeCP2E2 Isoforms Suggests Negative Auto-Regulatory Feedback that can be Moderated by Metformin-Reference-Cited by-同舟云学术

Transcriptional Inhibition of the Mecp2 Promoter by MeCP2E1 and MeCP2E2 Isoforms Suggests Negative Auto-Regulatory Feedback that can be Moderated by Metformin

Published:2024-01-26 Issue:1 Volume:74 Page:
ISSN:1559-1166
Container-title:Journal of Molecular Neuroscience
language:en
Short-container-title:J Mol Neurosci

Author:

Lockman Sandhini,Genung Matthew,Sheikholeslami Kimia,Sher Annan Ali,Kroft Daniel,Buist Marjorie,Olson Carl O.,Toor Brian,Rastegar Mojgan

Funder

Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant

University of Manitoba

Ontario Rett Syndrome Association

Publisher

Springer Science and Business Media LLC

Link

https://link.springer.com/content/pdf/10.1007/s12031-023-02177-0.pdf

Reference47 articles.

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2. Amiri S, Davie JR, Rastegar M (2020) Chronic ethanol exposure alters DNA methylation in neural stem cells: role of mouse strain and sex. Mol Neurobiol 57(2):650–667

3. Buist M, El Tobgy N, Shevkoplyas D, Genung M, Sher AA, Pejhan S et al (2022) Differential sensitivity of the protein translation initiation machinery and mTOR signaling to MECP2 gain- and loss-of-function involves MeCP2 isoform-specific homeostasis in the brain. Cells 11(9)

4. Buist M, Fuss D, Rastegar M (2021) Transcriptional regulation of MECP2E1-E2 isoforms and BDNF by metformin and simvastatin through analyzing nascent RNA synthesis in a human brain cell line. Biomolecules 11(8)

5. Chahrour M, Jung SY, Shaw C, Zhou X, Wong ST, Qin J et al (2008) MeCP2, a key contributor to neurological disease, activates and represses transcription. Science 320(5880):1224–1229

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