Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer

Author:

Sarsour Ehab H.ORCID,Son Jyung Mean,Kalen Amanda L.,Xiao Wusheng,Du Juan,Alexander Matthew S.,O'Leary Brianne R.,Cullen Joseph J.,Goswami Prabhat C.ORCID

Funder

HHS | National Institutes of Health

Kansas City University of Medicine and Biosciences Intramural Grant Discovery Program

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference49 articles.

1. Pancreatic cancer;Hidalgo;N. Engl. J. Med.,2010

2. Chemotherapy and radiotherapy for inoperable advanced pancreatic cancer;Yip;Cochrane Database Syst. Rev.,2006

3. 15-Lipoxygenase 2 (15-LOX2) is a functional tumor suppressor that regulates human prostate epithelial cell differentiation, senescence, and growth (size);Tang;Prostaglandins Other Lipid Mediat,2007

4. Targeting the tumor microenvironment: from understanding pathways to effective clinical trials;Fang;Cancer Res.,2013

5. Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes;Kadaba;J. Pathol,2013

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