Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes

Author:

Kadaba Raghu12,Birke Hanna3,Wang Jun4,Hooper Steven5,Andl Claudia D6,Di Maggio Francesco1,Soylu Erdinc1,Ghallab Mohammed12,Bor Daniel1,Froeling Fieke EM1,Bhattacharya Satyajit2,Rustgi Anil K7,Sahai Erik5,Chelala Claude4,Sasieni Peter3,Kocher Hemant M12

Affiliation:

1. Centre for Tumour Biology, Barts and the London School of Medicine and Dentistry; Queen Mary University of London; UK

2. Barts and the London HPB Centre; Royal London Hospital; UK

3. Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry; Queen Mary University of London; UK

4. Centre for Molecular Oncology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry; Queen Mary University of London; UK

5. Cancer Research UK London Research Institute; UK

6. Surgery and Cancer Biology; Vanderbilt University; Nashville TN USA

7. Division of Gastroenterology, Departments of Medicine and Genetics, Abramson Cancer Center; University of Pennsylvania Perelman School of Medicine; Philadelphia PA USA

Publisher

Wiley

Subject

Pathology and Forensic Medicine

Reference46 articles.

1. The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma;Erkan;Clin Gastroenterol Hepatol,2008

2. α-Smooth muscle actin expressing stroma promotes an aggressive tumor biology in pancreatic ductal adenocarcinoma;Fujita;Pancreas,2010

3. Tumor:stroma ratio is an independent predictor for survival in esophageal squamous cell carcinoma;Wang;J Thorac Oncol,2012

4. MMP inhibition blocks fibroblast-dependent skin cancer invasion, reduces vascularization and alters VEGF-A and PDGF-BB expression;Woenne;Anticancer Res,2012

5. Hallmarks of cancer: the next generation;Hanahan;Cell,2011

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