Mapping the Binding Site of the Inhibitor Tariquidar That Stabilizes the First Transmembrane Domain of P-glycoprotein
Author:
Funder
Canadian Institutes of Health Research
Cystic Fibrosis Canada
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference69 articles.
1. Mammalian abc transporters in health and disease;Borst;Annu. Rev. Biochem,2002
2. Tariquidar inhibits P-glycoprotein drug efflux but activates ATPase activity by blocking transition to an open conformation;Loo;Biochem. Pharmacol,2014
3. A pilot study to assess the efficacy of tariquidar to inhibit P-glycoprotein at the human blood-brain barrier with (R)-11C-verapamil and PET;Wagner;J. Nucl. Med,2009
4. The “specific” P-glycoprotein inhibitor tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2);Kannan;ACS Chem. Neurosci,2011
5. Correction of defective protein kinesis of human P-glycoprotein mutants by substrates and modulators;Loo;J. Biol. Chem,1997
Cited by 41 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Mutational analysis reveals the importance of residues of the access tunnel inhibitor site to human P‐glycoprotein (ABCB1)‐mediated transport;Protein Science;2024-08-28
2. Structural insight into binding site access and ligand recognition by human ABCB1;2024-08-12
3. Coupling the role of lipids to the conformational dynamics of the ABC transporter P-glycoprotein;Biophysical Journal;2024-08
4. Coupling the role of lipids to the conformational dynamics of the ABC transporter P-gp;2024-04-22
5. Second-site suppressor mutations reveal connection between the drug-binding pocket and nucleotide-binding domain 1 of human P-glycoprotein (ABCB1);Drug Resistance Updates;2023-11
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3