Evidence That Does Not Support Pyruvate Kinase M2 (PKM2)-catalyzed Reaction as a Rate-limiting Step in Cancer Cell Glycolysis
Author:
Funder
China National 973 project
National Natural Science Foundation of China
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference50 articles.
1. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth;Christofk;Nature,2008
2. Switching of pyruvate kinase isoform L to M2 promotes metabolic reprogramming in hepatocarcinogenesis;Wong;PLoS ONE,2014
3. Regulation of M2-type pyruvate kinase from human meningioma by allosteric effectors fructose 1,6 diphosphate and l-alanine;Mellati;Cancer Biochem. Biophys,1992
4. Pyruvate kinase M2 is a phosphotyrosine-binding protein;Christofk;Nature,2008
5. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses;Anastasiou;Science,2011
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