Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses-Reference-Cited by-同舟云学术

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

Published:2011-12-02 Issue:6060 Volume:334 Page:1278-1283
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Anastasiou Dimitrios¹²,Poulogiannis George¹²,Asara John M.¹³,Boxer Matthew B.⁴,Jiang Jian-kang⁴,Shen Min⁴,Bellinger Gary¹⁵,Sasaki Atsuo T.¹²,Locasale Jason W.¹²,Auld Douglas S.⁴,Thomas Craig J.⁴,Vander Heiden Matthew G.⁵⁶,Cantley Lewis C.¹²

Affiliation:

1. Beth Israel Deaconess Medical Center, Department of Medicine-Division of Signal Transduction, Boston, MA 02115, USA.

2. Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

3. Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

4. NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA.

5. Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

6. Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

Abstract

The glycolytic metabolism of cancers differs from normal tissues, allowing tumor cells to survive under oxidative stress.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference28 articles.

1. Redox Redux: Revisiting PTPs and the Control of Cell Signaling

2. Cellular Metabolic Stress: Considering How Cells Respond to Nutrient Excess

3. c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function

4. Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

5. The antioxidant function of the p53 tumor suppressor

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