Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing-Reference-Cited by-同舟云学术

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Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing

Published:2017-12 Issue:48 Volume:292 Page:19814-19825
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

Hoyte Ashley C.,Jamin Augusta V.,Koneru Pratibha C.,Kobe Matthew J.,Larue Ross C.,Fuchs James R.,Engelman Alan N.,Kvaratskhelia Mamuka

Funder

National Institutes of Health

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference41 articles.

1. Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication;Christ;Nat. Chem. Biol,2010

2. Discovery of BI 224436, a noncatalytic site integrase inhibitor (NCINI) of HIV-1;Fader;ACS Med. Chem. Lett,2014

3. New class of HIV-1 integrase (IN) inhibitors with a dual mode of action;Tsiang;J. Biol. Chem,2012

4. Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage;Le Rouzic;Retrovirology,2013

5. The allosteric HIV-1 integrase inhibitor BI-D affects virion maturation but does not influence packaging of a functional RNA genome;van Bel;PLoS One,2014

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1. Modeling and Analysis of HIV-1 Pol Polyprotein as a Case Study for Predicting Large Polyprotein Structures;International Journal of Molecular Sciences;2024-02-02

2. The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir;2024-01-26

3. Integrase;Metalloenzymes;2024

4. The Integrase: An Overview of a Key Player Enzyme in the Antiviral Scenario;International Journal of Molecular Sciences;2023-07-29

5. Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 Å resolution: Routes to inhibitor optimization;PLOS Pathogens;2023-03-03

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