Deletion of the neural tube defect–associated gene disrupts one-carbon and central energy metabolism in mouse embryos

Author:

Bryant Joshua D.,Sweeney Shannon R.,Sentandreu Enrique,Shin Minhye,Ipas Hélène,Xhemalce Blerta,Momb Jessica,Tiziani Stefano,Appling Dean R.

Funder

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

HHS | NIH | National Institute of General Medical Sciences (NIGMS)

Welch Foundation

University of Texas System (UT)

HHS | NIH | National Cancer Institute (NCI)

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference41 articles.

1. Folic acid food fortification-its history, effect, concerns, and future directions;Crider;Nutrients,2011

2. Finding the genetic mechanisms of folate deficiency and neural tube defects: leaving no stone unturned;Au;Am. J. Med. Genet. Pt. A,2017

3. Compartmentalization of mammalian folate-mediated one-carbon metabolism;Tibbetts;Annu. Rev. Nutr,2010

4. Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice;Momb;Proc. Natl. Acad. Sci. U.S.A,2013

5. In vitro evidence for the involvement of mitochondrial folate metabolism in the supply of cytoplasmic one-carbon units;Barlowe;Biofactors,1988

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