Lack of Evidence for the Involvement of the Phosphoinositide 3-Kinase/Akt Pathway in the Activation of Hypoxia-inducible Factors by Low Oxygen Tension-Reference-Cited by-同舟云学术

Lack of Evidence for the Involvement of the Phosphoinositide 3-Kinase/Akt Pathway in the Activation of Hypoxia-inducible Factors by Low Oxygen Tension

Published:2002-04 Issue:16 Volume:277 Page:13508-13517
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

Alvarez-Tejado Miguel,Alfranca Arántzazu,Aragonés Julian,Vara Alicia,Landázuri Manuel O.,del Peso Luis

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference57 articles.

1. Regulation of hypoxia-inducible factor 1 is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

2. Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations

3. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

4. HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing

5. Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

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