Distortion of the Catalytic Domain of Tissue-type Plasminogen Activator by Plasminogen Activator Inhibitor-1 Coincides with the Formation of Stable Serpin-Proteinase Complexes
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference35 articles.
1. The Molecular Basis for Anti-Proteolytic and Non-Proteolytic Functions of Plasminogen Activator Inhibitor Type-1: Roles of the Reactive Centre Loop, the Shutter Region, the Flexible Joint Region and the Small Serpin Fragment
2. Divining the serpin inhibition mechanism: a suicide substrate ‘springe’?
3. Structure of a serpin–protease complex shows inhibition by deformation
4. Intrinsic fluorescence changes and rapid kinetics of proteinase deformation during serpin inhibition
5. Insight into the Mechanism of Serpin−Proteinase Inhibition from 2D [1H-15N] NMR Studies of the 69 kDa α1-Proteinase Inhibitor Pittsburgh−Trypsin Covalent Complex
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1. Intracellular tPA–PAI-1 interaction determines VLDL assembly in hepatocytes;Science;2023-09
2. A Narrative Review on Plasminogen Activator Inhibitor-1 and Its (Patho)Physiological Role: To Target or Not to Target?;International Journal of Molecular Sciences;2021-03-08
3. Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484;International Journal of Molecular Sciences;2021-02-02
4. Targeting PAI-1 in Cardiovascular Disease: Structural Insights Into PAI-1 Functionality and Inhibition;Frontiers in Cardiovascular Medicine;2020-12-22
5. Molecular mechanism of two nanobodies that inhibit PAI‐1 activity reveals a modulation at distinct stages of the PAI‐1/plasminogen activator interaction;Journal of Thrombosis and Haemostasis;2020-02-20
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