Molecular mechanism of two nanobodies that inhibit PAI‐1 activity reveals a modulation at distinct stages of the PAI‐1/plasminogen activator interaction-Reference-Cited by-同舟云学术

Molecular mechanism of two nanobodies that inhibit PAI‐1 activity reveals a modulation at distinct stages of the PAI‐1/plasminogen activator interaction

Published:2020-02-20 Issue:3 Volume:18 Page:681-692
ISSN:1538-7933
Container-title:Journal of Thrombosis and Haemostasis
language:en
Short-container-title:J Thromb Haemost

Author:

Sillen Machteld¹^ORCID,Weeks Stephen D.²^ORCID,Zhou Xiaohua¹,Komissarov Andrey A.³^ORCID,Florova Galina³,Idell Steven³^ORCID,Strelkov Sergei V.²^ORCID,Declerck Paul J.¹^ORCID

Affiliation:

1. Laboratory for Therapeutic and Diagnostic Antibodies Department of Pharmaceutical and Pharmacological Sciences KU Leuven Leuven Belgium

2. Laboratory for Biocrystallography Department of Pharmaceutical and Pharmacological Sciences KU Leuven Leuven Belgium

3. Department of Cellular and Molecular Biology The University of Texas Health Science Center Tyler TX USA

Publisher

Wiley

Subject

Hematology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/jth.14716

Reference59 articles.

1. Venous thrombosis risk associated with plasma hypofibrinolysis is explained by elevated plasma levels of TAFI and PAI-1

2. High Plasminogen Activator Inhibitor and Tissue Plasminogen Activator Levels in Plasma Precede a First Acute Myocardial Infarction in Both Men and Women

3. Abnormally high circulation levels of tissue plasminogen activator and plasminogen activator inhibitor-1 in patients with a history of ischemic stroke.

4. A Novel Inhibitor of Plasminogen Activator Inhibitor-1 Provides Antithrombotic Benefits Devoid of Bleeding Effect in Nonhuman Primates

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