Kinetic Characterization of Bifunctional Thymidylate Synthase-Dihydrofolate Reductase (TS-DHFR) from Cryptosporidium hominis
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference31 articles.
1. Structure of and kinetic channelling in bifunctional dihydrofolate reductase–thymidylate synthase
2. Insights into antifolate resistance from malarial DHFR-TS structures
3. Phylogenetic Classification of Protozoa Based on the Structure of the Linker Domain in the Bifunctional Enzyme, Dihydrofolate Reductase-Thymidylate Synthase
4. Potential antifolate resistance determinants and genotypic variation in the bifunctional dihydrofolate reductase-thymidylate synthase gene from human and bovine isolates of Cryptosporidium parvum
5. Mechanistic Characterization of Toxoplasma gondiiThymidylate Synthase (TS-DHFR)-Dihydrofolate Reductase
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1. Targeting the TS dimer interface in bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa: Virtual screening identifies novel TS allosteric inhibitors;Bioorganic & Medicinal Chemistry Letters;2020-08
2. Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors;European Journal of Medicinal Chemistry;2019-12
3. Understanding the structural basis of species selective, stereospecific inhibition for Cryptosporidium and human thymidylate synthase;FEBS Letters;2019-06-18
4. Novel allosteric covalent inhibitors of bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa identified by virtual screening;Bioorganic & Medicinal Chemistry Letters;2019-06
5. Parallel reaction pathways and noncovalent intermediates in thymidylate synthase revealed by experimental and computational tools;Proceedings of the National Academy of Sciences;2018-09-24
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