Non-equivalent Ligand Selectivity of Agonist Sites in (α4β2)2α4 Nicotinic Acetylcholine Receptors

Author:

Mazzaferro Simone,Gasparri Federica,New Karina,Alcaino Constanza,Faundez Manuel,Iturriaga Vasquez Patricio,Vijayan Ranjit,Biggin Philip C.,Bermudez Isabel

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference40 articles.

1. Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors hα2β2, hα2β4, hα3β2, hα2β4, hα4β2, hα4β4 and hα7 expressed in Xenopus oocytes;Chavez-Noriega;J. Pharmacol. Exp. Ther,1997

2. Reversal of agonist selectivity by mutations of conserved amino acids in the binding site of nicotinic acetylcholine receptors;Horenstein;J. Biol. Chem,2007

3. Crystal structures of a cysteine-modified mutant in loop D of acetylcholine-binding protein;Brams;J. Biol. Chem,2011

4. Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor;Hibbs;EMBO J,2009

5. Molecular actions of smoking cessation drugs at α4β2 nicotinic receptors defined in crystal structures of a homologous binding protein;Billen;Proc. Natl. Acad. Sci. U.S.A,2012

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