Affiliation:
1. Beihang University
2. Beijing Transcend Vivoscope Biotech Co., Ltd.
3. LUSTER LightTech Co., Ltd.
4. University of Chinese Academy of Sciences
5. Chinese Academy of Sciences
6. Peking University
Abstract
We demonstrate a miniature fiber-optic two two-photon endomicroscopy with microsphere-spliced double-cladding antiresonant fiber for resolution enhancement. An easy-to-operate process for fixing microsphere permanently in an antiresonant fiber core, by arc discharge, is proposed. The flexible fiber-optic probe is integrated with a parameter of 5.8 mm × 49.1 mm (outer diameter × rigid length); the field of view is 210 µm, the resolution is 1.3 µm, and the frame rate is 0.7 fps. The imaging ability is verified using ex-vivo mouse kidney, heart, stomach, tail tendon, and in-vivo brain neural imaging.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Subject
Atomic and Molecular Physics, and Optics
Cited by
4 articles.
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