Trace Determination of Cardiac Troponin I Using a Label-Free Fiber Optical Localized Surface Plasmon Resonance Biosensors

Abstract

This work proposes a carboxyl-graphene-oxide-based fiber optic localized surface plasmon resonance biosensor which employed anti-Cardiac Troponin I (anti-cTnI) as the recognition element to detect the cTnI-protein in 10 min with a limit of detection (LOD) of 5.8 pM, which meets the acceptable LOD for clinical testing of 0.04 ng/mL.