Affiliation:
1. University of Tsukuba
2. Sky technology Inc.
3. Medical University of Vienna
4. St. Anna Children’s Cancer Research Institute
Abstract
Here we demonstrate a long-depth-of-focus imaging method using polarization sensitive optical coherence tomography (PS-OCT). This method involves a combination of Fresnel-diffraction-model-based phase sensitive computational refocusing and Jones-matrix based PS-OCT (JM-OCT). JM-OCT measures four complex OCT images corresponding to four polarization channels. These OCT images are computationally refocused as preserving the mutual phase consistency. This method is validated using a static phantom, postmortem zebrafish, and ex vivo porcine muscle samples. All the samples demonstrated successful computationally-refocused birefringence and degree-of-polarization-uniformity (DOPU) images. We found that defocusing induces polarization artifacts, i.e., incorrectly high birefringence values and low DOPU values, which are substantially mitigated by computational refocusing.
Funder
Core Research for Evolutional Science and Technology
Japan Science and Technology Agency
Japan Society for the Promotion of Science
China Scholarship Council
Austrian Science Fund
Subject
Atomic and Molecular Physics, and Optics,Biotechnology
Cited by
9 articles.
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