Affiliation:
1. Guilin University of Electronic Technology
2. Duke-NUS Medical School
3. Changsha University
Abstract
We propose a method for diagnosis of cirrhosis and hepatocellular carcinoma (HCC) by using a terahertz (THz) metamaterial (MM) biosensor. The biosensor has a resonance frequency at about 0.801 THz and can measure the concentration of alpha-fetoprotein (AFP) in serum. The sensitivity of the sensor is 124 GHz/refractive index unit (RIU), and the quality-factor (Q) is 6.913, respectively. When the surface of the biosensor is covered with healthy serum (
A
F
P
≤
7
n
g
/
m
L
), the maximum resonance frequency shift is 50 GHz. However, when it is covered with serum from patients with cirrhosis and early HCC (
A
F
P
>
7
n
g
/
m
L
), the resonance frequency shift is more than 59 GHz. Positive correlation exists between the frequency shift of the biosensor and serum levels of the AFP in the HCC patients. This study provides a method for quick diagnosis and prediction of cirrhosis and HCC.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Guangxi China
Innovation Project of Guangxi Graduate Education, China
Guangxi Key Laboratory of Automatic Detection Technology and Instrument Foundation
Key R & D Project in Hunan Province
Foundation of Hunan Provincial Education Department
Guilin University of Electronic Technology Postgraduate Training Program
Health Commission of Guangxi Zhuang Autonomous Region
Subject
Atomic and Molecular Physics, and Optics,Engineering (miscellaneous),Electrical and Electronic Engineering
Cited by
7 articles.
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