Cerebrovascular Disorders Associated with Ph-Negative Myeloproliferative Diseases-Reference-Cited by-同舟云学术

Cerebrovascular Disorders Associated with Ph-Negative Myeloproliferative Diseases

Published:2019 Issue:4 Volume:12 Page:38-45
ISSN:1997-6933
Container-title:Clinical oncohematology
language:
Short-container-title:Клиническая онкогематология

Author:

Tanashyan M.M.¹^ORCID,Kuznetsova Polina Igorevna¹^ORCID,Melikyan A.L.²^ORCID,Raskurazhev A.A.¹^ORCID

Affiliation:

1. Research Center of Neurology

2. National Research Center for Hematology

Abstract

Background. Cerebrovascular disorders continue to be among the most common and socially significant worldwide. Among multiple reasons for circulatory disturbances special importance is attached to hemorheology and hemostasis disorders occurring also in patients with Ph-negative myeloproliferative diseases (MPD). Aim. To investigate typical characteristics of the course of cerebrovascular disorders in patients with Ph-negative MPD. Materials & Methods. The trial included 169 adult patients with neurological diseases. Among them the main group consisted of 104 patients aged 34 to 55 years (median 48.5 years) with Ph-negative MPD diagnosed at the National Research Center for Hematology. The control group consisted of 65 patients aged 51 to 58 years (median 55.5 years) with cerebrovascular diseases without concomitant hematological pathology. Results. The incidence of acute ischemic strokes was 26.2 % in polycythemia vera (PV), 20.5 % in essential thrombocythe-mia (ET), and 8.7 % in primary myelofibrosis (PMF). Conclusion. An acute ischemic stroke with a concurrent thrombotic occlusion of one of the major head arteries is a criterion for ruling out Ph-negative MPD. To identify cerebral lesions in patients with Ph-negative MPD (PV, ET, PMF) MRI of the brain is recommended.

Publisher

Practical Medicine Publishing House

Subject

Oncology,Hematology

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