Creatinine and HMH (5-hydroxy-1-methylhydantoin, NZ-419) as intrinsic hydroxyl radical scavengers
Author:
Affiliation:
1. Nippon Zoki Pharmaceutical Co., Ltd
2. Institute of Natural Medicine, University of Toyama
Publisher
International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)
Subject
Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics,General Medicine
Reference61 articles.
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2. 2. Aoyagi K, Nagase S, Koyama A, Narita M, Tojo S. Products of creatinine with hydroxyl radical as a useful marker of oxidative stress in vivo. Methods Mol Biol. 1998; 108:157-164.
3. 3. Ienaga K, Mikami H, Takeuchi S, Nakamura K, Yokozawa T, Oura H, Aoyagi K, Nakano K, Endou H. NZ-419, an intrinsic antioxidant, as a therapeutic agent against progressive chronic renal failure and guanidino compounds. In: Guanidino Compounds (Mori A, Ishida M, Clark JF, eds.). Blackwell Science Asia Pty Ltd., 1999; pp. 131-138.
4. 4. Ienaga K, Nakamura K, Fujisawa T, Fukunaga Y, Nihei H, Narita M, Tomino Y, Sanaka T, Aoyagi K, Nakano K, Koide H. Urinary excretion of creatol, an in vivo biomarker of hydroxyl radical, in patients with chronic renal failure. Ren Fail. 2007; 29:279-283.
5. 5. Ienaga K, Mikami H, Yokozawa T. First indications demonstrating the preventive effects of NZ-419, a novel intrinsic antioxidant, on the initiation and/or progression of chronic renal failure in rats. Biol Pharm Bull. 2009; 32:1204-1208.
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