Nanoparticles Enable Efficient Delivery of Antimicrobial Peptides for the Treatment of Deep Infections

Author:

Deng Yingxue1,Huang Rui1,Huang Songyin2,Xiong Menghua1

Affiliation:

1. School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, Guangdong 510006, P. R. China

2. Center for Biotherapy, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, P. R. China

Abstract

Abstract Antimicrobial peptides (AMPs) have emerged as promising alternatives of traditional antibiotics against drug-resistant bacteria owing to their broad-spectrum antimicrobial properties and low tendency to drug resistance. However, their therapeutic efficacy in vivo, especially for infections in deep organs, is limited owing to their systemic toxicity and low bioavailability. Nanoparticles-based delivery systems offer a strategy to increase the therapeutic index of AMPs by preventing proteolysis, increasing the accumulation at infection sites, and reducing toxicity. Herein, we will discuss the current progress of using nanoparticles as delivery vehicles for AMPs for the treatment of deep infections.Statement of significanceAntimicrobial peptides (AMPs) are rarely directly used to treat deep infections due to their systemic toxicity and low bioavailability. This review summarizes recent progress that researchers employed nanoparticles-based delivery systems to deliver AMPs for the treatment of deep infections. Nanoparticles-based delivery systems offer a strategy to increase the therapeutic index of AMPs by preventing proteolysis, increasing the accumulation at infection sites, and reducing toxicity. Especially, the development of intelligent nanocarriers can achieve selective activation and active target in the infectious sites, thus improving the therapeutic efficacy against bacterial infection and reducing the toxicity against normal tissues.

Publisher

Compuscript, Ltd.

Reference54 articles.

1. Antimicrobial resistance 2020

2. A broad-spectrum antibiotic adjuvant reverses multidrug-resistant Gram-negative pathogens;Song;Nat Microbiol,2020

3. Antibacterial hydrogels;Li;Adv Sci (Weinh),2018

4. Antimicrobial host defence peptides: functions and clinical potential;Mookherjee;Nat Rev Drug Discov,2020

5. APD3: the antimicrobial peptide database as a tool for research and education;Wang;Nucleic Acids Res,2016

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