Successful Renal Transplant in End-Stage Renal Disease with Chronic Immune Thrombocytopenia using Thrombopoietin Receptor Agonists and Intravenous Immunoglobulin

Author:

Behera Vineet1,K.P. Rohith2,Chauhan Prabhat3,Meshram Ashok4,Dhawan Vikas5,Ananthakrishnan Ramamoorthy6,Hande Vivek7

Affiliation:

1. Nephrologist and Associate Professor Medicine, INHS Asvini, Mumbai, Maharashtra, India

2. Senior Resident Medicine, INHS Asvini, Mumbai, Maharashtra, India

3. Nephrologist, INHS Asvini, Mumbai, Maharashtra, India

4. Hematologist, INHS Asvini, Mumbai, Maharashtra, India

5. Urologist, INHS Asvini, Mumbai, Maharashtra, India

6. Professor Medicine and Cardiology, INHS Asvini, Mumbai, Maharashtra, India

7. Professor Medicine and Gastroenterology, INHS Asvini, Mumbai, Maharashtra, India

Abstract

Chronic kidney disease in immune thrombocytopenia (ITP) is uncommon, and renal transplant in this setting is rare. We discuss the successful renal transplant of a 29-year-old male with chronic ITP. During transplant, he was managed with thrombopoietin receptor agonist eltrombopag, intravenous methylprednisone, and intravenous immunoglobulin to maintain adequate platelet level. He recovered well with no major complications and good graft function and has been stable during the follow-up period. The case report highlights that renal transplantation is a feasible option in patients with ITP, even in the presence of low platelet counts.

Publisher

Scientific Scholar

Reference10 articles.

1. Updated international consensus report on the investigation and management of primary immune thrombocytopenia;Provan;Blood Adv,2019

2. Renal transplantation and idiopathic thrombocytopenic purpura;Takahara;Clin Transpl,1986

3. Haemostasis in chronic kidney disease;Lutz;Nephrol Dial Transplant,2014

4. Renal transplantation in idiopathic thrombocytopenic purpura;Kanodia;Saudi J Kidney Dis Transplant,2013

5. Renal transplantation in a patient with idiopathic thrombocytopenic purpura;Hwang;Korean J Intern Med,2005

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