Oxidative Stress and Inflammatory Response Interplay

Abstract

Oxidative stress and inflammatory responses are two highly related processes that, when interacted with, can have profound health consequences. Oxidative stress refers to an imbalance between the production of reactive oxygen species and the body's antioxidant defense mechanisms, and the inflammatory response is the body's response to injury, infection, or tissue damage. This work was designed to review the relationship between oxidative stress and inflammatory response to provide useful information. Relevant and accurate literature were sourced from WHO. CDC, NCDC, PubMed, Scopus, PLoS One, and NATURE journals. Interference between these two processes can lead to accelerated aging, cardiovascular diseases, cancer, and neurological diseases. Maintaining a balance between oxidative stress and the inflammatory response is critical to promoting overall health and preventing the progression of chronic disease. Several knowledge and research gaps were found and reported in this study. Oxidative stress and inflammatory responses are closely related, and their dysregulation may play a role in the pathogenesis of many medical conditions, including cardiovascular disease, neurological disease, and cancer. Management of oxidative stress and inflammation through lifestyle modification and medical interventions, including appropriate attention to the knowledge and research gaps identified in this work, could provide significant therapeutic benefits in these conditions.