Waning of Antibody Response Among Vaccinees who Received Two Doses of Covishield Vaccine

Author:

Haritay Shivani1,Patil Rithia2,Maldar Arif3,Kumar Anil1,Reddy Vikrama1,Oswal Deshna1,Tahashildar Masood Ahmed2,Kolakar Akshay1,Kabbur Satish1,Prasad Jang Bahadur4,Shivaswamy M. S.5,Paranjape Ramesh2,Angolkar Mubashir1

Affiliation:

1. Department of Public Health, KLE Academy of Higher Education and Research, Belgaum, Karnataka, India

2. Dr. Prabhakar Kore BSRC, KLE Academy of Higher Education and Research, Belgaum, Karnataka, India

3. J. N. Medical College, KLE Dr. Prabhakar Kore Charitable Hospital, Belgaum, Karnataka, India

4. Department of Biostatistics, KLE Academy of Higher Education and Research, Belgaum, Karnataka, India

5. Department of Community Medicine, J. N. Medical College, KLE Academy of Higher Education and Research, Belgaum, Karnataka, India

Abstract

Introduction: There are limited data available on the long-term presence of SARS-CoV-2-specific binding antibodies and neutralizing antibodies in circulation among the elderly population. This study aims to examine levels of anti-SARS-CoV-2 antibodies in vaccines who have completed at least 6 months since the second vaccine dose. A cross-sectional study was conducted from November 2021 to January 2022 among 199 vaccines aged 60 years and above residing in Belagavi city, who received two doses of the Covishield vaccine. Methods: Antibody response to SARS-COV-2 virus whole cell antigen was measured by a kit COVID KAWACH IgG Micro LISA (J Mitra and Company, India) in 199 participants who had completed at least 6 months after receiving the second dose of Covishield vaccine. The antibody response was measured as a ratio of optical density (OD) in the participant’s sample to the mean OD in negative control test by normal (T/N). Independent Kruskal–Wallis test was applied to test the difference between the T/N ratio by months of vaccination since the second dose and by the age group strata. Results: The median T/N values among participants who completed 6, 7, 8, and 9 months since the second vaccine dose were 14.17, 10.46, 7.93, and 5.11, respectively, and this decline in T/N values was statistically significant. Antibody response values showed a decline with increasing age for participants in the age strata 60–69, 70–79, and 80 and above, respectively. Conclusions: A significant decline was observed in antibody response over 9 months supporting the administration of booster dose of vaccine.

Publisher

Medknow

Subject

Infectious Diseases

Reference13 articles.

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4. Immune response to SARS-CoV-2 in health care workers following a COVID-19 outbreak: A prospective longitudinal study;Fill Malfertheiner;J Clin Virol,2020

5. Vaccine effectiveness and duration of protection of Comirnaty, Vaxzevria and Spikevax against mild and severe COVID-19 in the UK;Andrews;medrxiv 2021 Sep 21 2021-09

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