A pharmacologic activator of endothelial KCa channels increases systemic conductance and reduces arterial pressure in an anesthetized pig model-Reference-Cited by-同舟云学术

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A pharmacologic activator of endothelial KCa channels increases systemic conductance and reduces arterial pressure in an anesthetized pig model

Published:2016-04 Issue: Volume:79 Page:24-31
ISSN:1537-1891
Container-title:Vascular Pharmacology
language:en
Short-container-title:Vascular Pharmacology

Author:

Mishra Ramesh C.,Mitchell Jamie R.,Gibbons-Kroeker Carol,Wulff Heike,Belenkie Israel,Tyberg John V.,Braun Andrew P.

Funder

Canadian Institutes of Health Research

National Institutes of Health

Kidney Foundation of Canada/Pfizer Canada

Publisher

Elsevier BV

Subject

Pharmacology,Molecular Medicine,Physiology

Reference38 articles.

1. Openers of SKCa and IKCa channels enhance agonist-evoked endothelial nitric oxide synthesis and arteriolar dilation;Sheng;FASEB J.,2009

2. Naphthol[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure;Sankaranarayanan;Mol. Pharmacol.,2009

3. Opening of small and intermediate calcium-activated potassium channels induces relaxation mainly mediated by nitric-oxide release in large arteries and endothelium-derived hyperpolarizing factor in small arteries from rat;Stankevicius;J. Pharmacol. Exp. Ther.,2011

4. Pharmacological activation of KCa3.1/KCa2.3 channels produces endothelial hyperpolarization and lowers blood pressure in conscious dogs;Damkjaer;Br. J. Pharmacol.,2012

5. Activation of KCa3.1 by SKA-31 induces arteriolar dilatation and lowers blood pressure in normo- and hypertensive connexin40-deficient mice;Radtke;Br. J. Pharmacol.,2013

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1. Endothelial KCa channels: Novel targets to reduce atherosclerosis-driven vascular dysfunction;Frontiers in Pharmacology;2023-03-31

2. KCa channel activation normalizes endothelial function in Type 2 Diabetic resistance arteries by improving intracellular Ca2+ mobilization;Metabolism;2021-01

3. Hydrophobic interactions between the HA helix and S4‐S5 linker modulate apparent Ca 2+ sensitivity of SK2 channels;Acta Physiologica;2020-09-10

4. SKA-31, an activator of Ca2+-activated K+ channels, improves cardiovascular function in aging;Pharmacological Research;2020-01

5. Recent Developments in the Pharmacology of Epithelial Ca2 +-Activated K+ Channels;Studies of Epithelial Transporters and Ion Channels;2020

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