Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954
Author:
Publisher
Elsevier BV
Subject
Pharmacology,Biochemistry
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2. 2,4-Dinitro-5-ethyleneiminobenzamide (CB 1954): a potent and selective inhibitor of the growth of the Walker carcinoma 256;Cobb;Biochem Pharmacol,1969
3. A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells;Knox;Biochem Pharmacol,1988
4. The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide);Boland;Biochem Pharmacol,1991
5. Cytosolic NAD(P)H:(quinone-acceptor)oxidoreductase in human normal and tumor tissue: effects of cigarette smoking and alcohol;Schlager;Int J Cancer,1990
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